It's brilliant. A metaphor for puberty, angst, and pubescent frustration set against a neon-tinted cyberpunk nightmare of a world filled with cults, dangerous "playing God" experimental science, a fascist government clique vs. a corrupt bloated one, and motorcycles.
I see it as a bit like A Clockwork Orange meets Brazil + The Fly.
It uses the medium to its advantage, making it live-action in 1988 would either have been really cheap looking or ridiculously expensive. It's also brilliantly animated without a single frame of CG. Look at the bit where they chase the clowns into the tunnel, or the epic crowd scenes, the massive pipes venting steam, the satellite firing, or the reactions of the motorists as the pursuing K9's are shot. Just don't listen to the English track. Yes it's violent, but there's thought behind it too. Besides, at least the compulsory anime mood swings make sense in this movie.
Really good for a 2 hour adaptation of a brilliant over 1000 page manga that took over 10 years to draw. The manga goes post-apocalyptic as the end of the film would only come at the half-way point of the volumes.
If it breaks, you get to keep both pieces.