Probably a stupid/simple question, but....

My high E string seems to be a bit quieter than the others. Open, it's kinda twangy, and I can't figure out why it's getting dampened... but it SUCKS.
So does anyone know how to un-suckify the string?

This is generally only a problem with non-distortion effects (although it happpens with some of my soft-distortion effects).

Try getting your intonation checked, or changing the string. Sorry I'm not more help :/

either your neck is crooked, or your bridge isn't well adjusted anymore. try to find out where the odd "twanng" seems to come from, and if it does it at every fret.

But get it checked by a luthier anyway.

When the action is too low on the guitar, it can cause the string(s) to buzz against the frets and/or fretboard, which would cause that "twang". Another thing is that sometimes the tuners on a guitar can get kinda loose over time, so that could also cause some sort of buzzing, I guess.

The best thing to do is probably just change the string, really.

Leave it twangy and start playing country!!!!!!!!!

^ NO!

The strings are all new, and the twang seems to be coming from the bridge, so I'm going to play with it and see if it helps.

I don't really know what you mean by twangy, but if it's buzzing then it could be that either a fret needs filing or (more likely) the action is set too low.

It does it when it's high, too, so that's not it. And it's definitely not the frets, because it's a relatively new guitar.