The amphetamines mentioned on the last page have documented physiological side effects and should never be taken, unlike the hallucinogenics or cannabis, as flirb mentioned. I could be on medications that a doctor prescribes and have serious problems with digestion or my heart, or I could self medicate a drug and experience its moderate side effects. I still wish we properly studied and refined these drugs for actual medicated use, but their inability to be patented dooms them to the streets. Cannabis can be cultivated and consumed in completely non-destructive and non-psychological ways to combat pain, or to gain its health benefits. Vaporized inhalers can be made from cannabis to treat children's asthma without any amount of psychoactive compounds present. Growers today understand the plant well enough to make these things, but there's more profit in the psychoactive compounds. The stigma and social understanding of these things really needs to change so we can actually use them for their benefits instead of making piecemeal with illicit dealers and word of mouth understanding.