If we stick with Cincinnati, I will be more than happy to help set up a schedule of things to do (based on what you guys want to do), print out maps for everyone to use, give some good ideas of hotels worth staying at here, and assuming I don't get sick, I'll drive some around/follow the leader
Also, you won't want to stay near Cincinnati's CVG airport, as it's nowhere near anything. It's actually just across the border (in Kentucky) and thus like a 40 minute drive to get anywhere.
Honestly, the best area might be the Mason area. Not only is it only a minute from the highway, but it has a lot of hotels to chose from, plenty of fast food/stores/etc. There's Wal-Mart, Wendy's, Arby's, Taco Bell, Skyline, McDonalds, White Castles, Waffle House, TGIF, Buffalo Wild Wings, Culvers, LaRosas, and about 50 other sit-in restaurants, tons of shopping for those who are into that, Kings Island, Regal movie theater, Marsto's (That LAN gaming center), and all that literally only 5 minutes or less from the hotels. Much of it is actually walking distance. There's also the the LaRoche castle about 10 minutes away, which although small is really damn cool (guy built it himself stone by stone).
And then jumping on the highway gets you to downtown Cincinnati in about 30 minutes, where the museums are.
http://ecincinnati.com/entertainment/events/ has a good summary of stuff to do in Cincinnati itself.