Tolterodine is an antimuscarinic drug that is used to treat urinary incontinence. It is sold under the trade names Detrol and Detrusitol.
Tolterodine acts on M1, M2, M3, M4 and M5 subtypes of muscarinic receptors whereas modern antimuscarinic treatments for overactive bladder only act on M3 receptors making them more selective. It is marketed and manufactured by Pfizer.
Tolterodine, although it acts on all types of receptors, has fewer side effects than other antimuscarinics eg. oxybutynin (M3 and M1 selective, but more so in the parotid than in the bladder) as tolterodine targets the bladder more than other areas of the body. This means that less drug needs to be given daily (due to efficient targeting of the bladder) and so there are fewer side effects.
Known Side Effects:
* Hyposalivation (Dry mouth)
* Decreased gastric motility (Upset stomach)
* Headache
* Constipation
* Dry eyes
* Sleepiness
Reports of Patients’ Experiences Since Detrol Became Available:
The following reactions have been reported in patients who have taken Detrol since it has become available:
* Allergic reactions including swelling
* Rapid heartbeat or abnormal heartbeat
* Accumulation of fluid in the arms and legs
* Hallucinations
Contraindications:
Not to be used in patients with Myasthenia Gravis and Angle Closure Glaucoma
Looks like we're not going down after all, so nevermind.